Author(s) Details:
Khaled Jadallah
Department of Internal Medicine, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Roberto De Giorgio
Department of Translational Sciences, University of Ferrara, Ferrara, Italy.
Rami Jadallah
Department of Internal Medicine, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
This section is a part of the chapter: Pharmacological Ad-vancements in the Management of Constipation-Predominant Irritable Bowel Syndrome: A Comprehensive Review
Current research estimates indicate that the global prevalence of IBS ranges from 5% to 35% (Oka et al. 2020, Sperber et al. 2021, Black and Ford 2020). Variations in the prevalence of the IBS-C subtype are observed across different regions. In China, it is reported that between 40% and 50% of individuals diagnosed with IBS are affected by the IBS-C subtype, in contrast to Western countries, where this proportion is notably lower, ranging from 11% to 20% (Sperber et al. 2021, Moshiree and Rao 2021, Lacy et al. 2021). The considerable variation in the prevalence of IBS across different regions is likely attributable to the diverse methodologies employed in diagnosing the condition, as well as the impact of ethnic background on these rates. On a global scale, approximately 34% of patients with IBS are identified as having the IBS-C subtype (Schaper and Stengel 2022, Madva et al. 2023, Staudacher et al 2021, Grover et al 2021, Drossman 2016, Black et al. 2021). Individuals diagnosed with IBS-C commonly experience a variety of symptoms. These include straining during bowel movements, the presence of hard stools, a feeling of incomplete evacuation, bloating, and abdominal pain that tend to improve after defecation (Staudacher 2021, Fang et al. 2024, Teige et al. 2024, Noor-Mohammadi et al. 2024).
How to Cite
Jadallah, K., Giorgio, R. D., & Jadallah, R. (2025). Pharmacological Advancements in the Management of Constipation-Predominant Irritable Bowel Syndrome: A Comprehensive Review. Medical Science: Trends and Innovations Vol. 4, 49–85. https://doi.org/10.9734/bpi/msti/v4/4177