Author(s) Details:
Avraham Mayevsky
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290092, Israel.
Michael Tolmasov
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290092, Israel.
Mira Mandelbaum
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290092, Israel.
This section is a part of the chapter: Real Time Assessment of Patients’ Body Oxygen Balance and Tissue Metabolic Score (TMS)
It is now 70 years since the significant work of Chance & Williams on mitochondrial metabolic state in vitro as summarized in Fig. 2, was published (Chance & Williams, 1955).
The discovery of the pyridine nucleotides was made by Harden & Young about 110 years ago (Harden & Young, 1906; 1905) and was followed by the description of its full structure by Warburg and collaborators 30 years later (Warburg et al., 1935). All those historical studies led to the first detailed experiments, by Chance et al. (Chance et al., 1962), in which NADH (Nicotine amide adenine dinucleotide) fluorescence, was used as a marker of mitochondrial function of the brain and kidney in vivo in anesthetized animals.
How to Cite
Mayevsky, A., Tolmasov, M., & Mandelbaum, M. (2025). Real Time Assessment of Patients’ Body Oxygen Balance and Tissue Metabolic Score (TMS). Medical Science: Trends and Innovations Vol. 4, 101–142. https://doi.org/10.9734/bpi/msti/v4/4146